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Southview Medical Center opened in 1978 as the "Ambulatory Care Center," an extension of Dayton's Grandview Medical Center. In 1983 an inpatient wing was added, creating the hospital as it's known today.

Rooted in the same osteopathic tradition as its sister hospital, Grandview, Southview provided rotations for interns, who functioned as residents by being the first physicians called to the bedside.

In 1999 Southview became part of Kettering Health Network, which provided an opportunity to continue its tradition and expand. Additions of the Yankee Medical Center and The Hand Center on Southview's campus followed.